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Computational limits to binary genes
Nicolae Radu Zabet and Dominique F. Chu
J. R. Soc. Interface, 7:182-196, June 2010 [doi].Abstract
We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficient h which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold K which minimizes noise.
Bibtex Record
@article{2969, author = {Nicolae Radu Zabet and Dominique F. Chu}, title = {Computational limits to binary genes}, month = {June}, year = {2010}, pages = {182-196}, keywords = {determinacy analysis, Craig interpolants}, note = {}, doi = {10.1098/rsif.2009.0474}, url = {http://www.cs.kent.ac.uk/pubs/2010/2969}, publication_type = {article}, submission_id = {1281_1260891902}, journal = {J. R. Soc. Interface}, publisher = {The Royal Society}, volume = {7}, }