Data Description file for Dataset: Neighbour Enrichment - KEGG Description: Dataset of target annotations collected using the Neibhour Enrichment function in STRING, which includes annotations from nearest neighbour proteins to the input target. The predictive features in this dataset refer only to KEGG Pathway annotations. Special Columns: Category Description Index ID Unique identifier for the compound/sex combination (instance) in the data. Ignored when training the classification model. Compound_name ID Name of the compound (drug). Ignored when training the classification model. class Target Variable Class label, with 0 indicating that the drug/sex combination is NOT associated with mouse longevity, and 1 indicating that it IS associated with mouse longevity, based on results from peer-reviewed studies. Predictive Features: Category Description hsa04024 KEGG Pathway cAMP signaling pathway hsa04080 KEGG Pathway Neuroactive ligand-receptor interaction hsa04923 KEGG Pathway Regulation of lipolysis in adipocytes hsa05220 KEGG Pathway Chronic myeloid leukemia hsa04110 KEGG Pathway Cell cycle hsa04919 KEGG Pathway Thyroid hormone signaling pathway hsa05203 KEGG Pathway Viral carcinogenesis hsa04330 KEGG Pathway Notch signaling pathway hsa05200 KEGG Pathway Pathways in cancer hsa05016 KEGG Pathway Huntington disease hsa01522 KEGG Pathway Endocrine resistance hsa05165 KEGG Pathway Human papillomavirus infection hsa05215 KEGG Pathway Prostate cancer hsa04310 KEGG Pathway Wnt signaling pathway hsa05161 KEGG Pathway Hepatitis B hsa05206 KEGG Pathway MicroRNAs in cancer hsa05202 KEGG Pathway Transcriptional misregulation in cancer hsa05167 KEGG Pathway Kaposi sarcoma-associated herpesvirus infection hsa05169 KEGG Pathway Epstein-Barr virus infection hsa05166 KEGG Pathway Human T-cell leukemia virus 1 infection hsa05219 KEGG Pathway Bladder cancer hsa04520 KEGG Pathway Adherens junction hsa05212 KEGG Pathway Pancreatic cancer hsa05214 KEGG Pathway Glioma hsa05218 KEGG Pathway Melanoma hsa05223 KEGG Pathway Non-small cell lung cancer hsa05222 KEGG Pathway Small cell lung cancer hsa04218 KEGG Pathway Cellular senescence hsa05224 KEGG Pathway Breast cancer hsa05226 KEGG Pathway Gastric cancer hsa05160 KEGG Pathway Hepatitis C hsa05225 KEGG Pathway Hepatocellular carcinoma hsa04371 KEGG Pathway Apelin signaling pathway hsa04915 KEGG Pathway Estrogen signaling pathway hsa05418 KEGG Pathway Fluid shear stress and atherosclerosis hsa05132 KEGG Pathway Salmonella infection hsa05216 KEGG Pathway Thyroid cancer hsa04612 KEGG Pathway Antigen processing and presentation hsa04151 KEGG Pathway PI3K-Akt signaling pathway hsa04657 KEGG Pathway IL-17 signaling pathway hsa04659 KEGG Pathway Th17 cell differentiation hsa04914 KEGG Pathway Progesterone-mediated oocyte maturation hsa04137 KEGG Pathway Mitophagy - animal hsa04917 KEGG Pathway Prolactin signaling pathway hsa05231 KEGG Pathway Choline metabolism in cancer hsa04926 KEGG Pathway Relaxin signaling pathway hsa05135 KEGG Pathway Yersinia infection hsa04921 KEGG Pathway Oxytocin signaling pathway hsa05130 KEGG Pathway Pathogenic Escherichia coli infection hsa05031 KEGG Pathway Amphetamine addiction hsa05120 KEGG Pathway Epithelial cell signaling in Helicobacter pylori infection hsa05140 KEGG Pathway Leishmaniasis hsa05133 KEGG Pathway Pertussis hsa04662 KEGG Pathway B cell receptor signaling pathway hsa04012 KEGG Pathway ErbB signaling pathway hsa04658 KEGG Pathway Th1 and Th2 cell differentiation hsa04912 KEGG Pathway GnRH signaling pathway hsa05210 KEGG Pathway Colorectal cancer hsa05235 KEGG Pathway PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05323 KEGG Pathway Rheumatoid arthritis hsa05142 KEGG Pathway Chagas disease hsa04620 KEGG Pathway Toll-like receptor signaling pathway hsa04625 KEGG Pathway C-type lectin receptor signaling pathway hsa04660 KEGG Pathway T cell receptor signaling pathway hsa04928 KEGG Pathway Parathyroid hormone synthesis, secretion and action hsa04668 KEGG Pathway TNF signaling pathway hsa04380 KEGG Pathway Osteoclast differentiation hsa04210 KEGG Pathway Apoptosis hsa05162 KEGG Pathway Measles hsa04932 KEGG Pathway Non-alcoholic fatty liver disease hsa04530 KEGG Pathway Tight junction hsa04621 KEGG Pathway NOD-like receptor signaling pathway hsa04510 KEGG Pathway Focal adhesion hsa05205 KEGG Pathway Proteoglycans in cancer hsa05170 KEGG Pathway Human immunodeficiency virus 1 infection hsa05131 KEGG Pathway Shigellosis hsa05163 KEGG Pathway Human cytomegalovirus infection hsa05100 KEGG Pathway Bacterial invasion of epithelial cells hsa05213 KEGG Pathway Endometrial cancer hsa05230 KEGG Pathway Central carbon metabolism in cancer hsa04141 KEGG Pathway Protein processing in endoplasmic reticulum hsa04010 KEGG Pathway MAPK signaling pathway hsa01521 KEGG Pathway EGFR tyrosine kinase inhibitor resistance hsa01524 KEGG Pathway Platinum drug resistance hsa04066 KEGG Pathway HIF-1 signaling pathway hsa05211 KEGG Pathway Renal cell carcinoma hsa04720 KEGG Pathway Long-term potentiation hsa04350 KEGG Pathway TGF-beta signaling pathway hsa04916 KEGG Pathway Melanogenesis hsa04922 KEGG Pathway Glucagon signaling pathway hsa04935 KEGG Pathway Growth hormone synthesis, secretion and action hsa04068 KEGG Pathway FoxO signaling pathway hsa04120 KEGG Pathway Ubiquitin mediated proteolysis hsa04630 KEGG Pathway JAK-STAT signaling pathway hsa05152 KEGG Pathway Tuberculosis hsa05164 KEGG Pathway Influenza A hsa04512 KEGG Pathway ECM-receptor interaction hsa04215 KEGG Pathway Apoptosis - multiple species hsa05145 KEGG Pathway Toxoplasmosis hsa04115 KEGG Pathway p53 signaling pathway hsa05134 KEGG Pathway Legionellosis hsa05168 KEGG Pathway Herpes simplex virus 1 infection hsa04217 KEGG Pathway Necroptosis hsa05416 KEGG Pathway Viral myocarditis hsa04064 KEGG Pathway NF-kappa B signaling pathway hsa05010 KEGG Pathway Alzheimer disease hsa05012 KEGG Pathway Parkinson disease hsa05020 KEGG Pathway Prion disease hsa05014 KEGG Pathway Amyotrophic lateral sclerosis hsa04390 KEGG Pathway Hippo signaling pathway hsa05034 KEGG Pathway Alcoholism hsa04713 KEGG Pathway Circadian entrainment hsa04727 KEGG Pathway GABAergic synapse hsa05032 KEGG Pathway Morphine addiction hsa04724 KEGG Pathway Glutamatergic synapse hsa04725 KEGG Pathway Cholinergic synapse hsa04726 KEGG Pathway Serotonergic synapse hsa04728 KEGG Pathway Dopaminergic synapse hsa04723 KEGG Pathway Retrograde endocannabinoid signaling hsa04062 KEGG Pathway Chemokine signaling pathway hsa04920 KEGG Pathway Adipocytokine signaling pathway hsa04934 KEGG Pathway Cushing syndrome hsa04971 KEGG Pathway Gastric acid secretion hsa05322 KEGG Pathway Systemic lupus erythematosus hsa04213 KEGG Pathway Longevity regulating pathway - multiple species hsa00760 KEGG Pathway Nicotinate and nicotinamide metabolism hsa04640 KEGG Pathway Hematopoietic cell lineage hsa01100 KEGG Pathway Metabolic pathways hsa04514 KEGG Pathway Cell adhesion molecules hsa05340 KEGG Pathway Primary immunodeficiency hsa00500 KEGG Pathway Starch and sucrose metabolism hsa04973 KEGG Pathway Carbohydrate digestion and absorption hsa00052 KEGG Pathway Galactose metabolism hsa04931 KEGG Pathway Insulin resistance hsa04970 KEGG Pathway Salivary secretion hsa04972 KEGG Pathway Pancreatic secretion hsa04910 KEGG Pathway Insulin signaling pathway hsa00524 KEGG Pathway Neomycin, kanamycin and gentamicin biosynthesis hsa00051 KEGG Pathway Fructose and mannose metabolism hsa00520 KEGG Pathway Amino sugar and nucleotide sugar metabolism hsa04930 KEGG Pathway Type II diabetes mellitus hsa00010 KEGG Pathway Glycolysis / Gluconeogenesis hsa01200 KEGG Pathway Carbon metabolism hsa04142 KEGG Pathway Lysosome hsa00590 KEGG Pathway Arachidonic acid metabolism hsa04913 KEGG Pathway Ovarian steroidogenesis hsa05144 KEGG Pathway Malaria hsa04933 KEGG Pathway AGE-RAGE signaling pathway in diabetic complications hsa05146 KEGG Pathway Amoebiasis hsa00591 KEGG Pathway Linoleic acid metabolism hsa01523 KEGG Pathway Antifolate resistance hsa05143 KEGG Pathway African trypanosomiasis hsa05332 KEGG Pathway Graft-versus-host disease hsa04216 KEGG Pathway Ferroptosis hsa04060 KEGG Pathway Cytokine-cytokine receptor interaction hsa04370 KEGG Pathway VEGF signaling pathway hsa05321 KEGG Pathway Inflammatory bowel disease hsa04623 KEGG Pathway Cytosolic DNA-sensing pathway hsa04664 KEGG Pathway Fc epsilon RI signaling pathway hsa04750 KEGG Pathway Inflammatory mediator regulation of TRP channels hsa04061 KEGG Pathway Viral protein interaction with cytokine and cytokine receptor hsa04072 KEGG Pathway Phospholipase D signaling pathway hsa05204 KEGG Pathway Chemical carcinogenesis hsa04924 KEGG Pathway Renin secretion hsa04925 KEGG Pathway Aldosterone synthesis and secretion hsa04114 KEGG Pathway Oocyte meiosis hsa04270 KEGG Pathway Vascular smooth muscle contraction hsa04261 KEGG Pathway Adrenergic signaling in cardiomyocytes hsa04020 KEGG Pathway Calcium signaling pathway hsa04014 KEGG Pathway Ras signaling pathway hsa04744 KEGG Pathway Phototransduction hsa04740 KEGG Pathway Olfactory transduction hsa04070 KEGG Pathway Phosphatidylinositol signaling system hsa04722 KEGG Pathway Neurotrophin signaling pathway hsa04022 KEGG Pathway cGMP-PKG signaling pathway hsa04015 KEGG Pathway Rap1 signaling pathway hsa04340 KEGG Pathway Hedgehog signaling pathway hsa05110 KEGG Pathway Vibrio cholerae infection hsa05030 KEGG Pathway Cocaine addiction hsa04961 KEGG Pathway Endocrine and other factor-regulated calcium reabsorption hsa04927 KEGG Pathway Cortisol synthesis and secretion hsa04918 KEGG Pathway Thyroid hormone synthesis hsa04742 KEGG Pathway Taste transduction hsa04911 KEGG Pathway Insulin secretion hsa04211 KEGG Pathway Longevity regulating pathway hsa04540 KEGG Pathway Gap junction hsa04976 KEGG Pathway Bile secretion hsa05414 KEGG Pathway Dilated cardiomyopathy hsa04611 KEGG Pathway Platelet activation hsa04140 KEGG Pathway Autophagy - animal hsa04714 KEGG Pathway Thermogenesis hsa00970 KEGG Pathway Aminoacyl-tRNA biosynthesis hsa00380 KEGG Pathway Tryptophan metabolism hsa00790 KEGG Pathway Folate biosynthesis hsa00350 KEGG Pathway Tyrosine metabolism hsa04721 KEGG Pathway Synaptic vesicle cycle hsa04730 KEGG Pathway Long-term depression hsa04670 KEGG Pathway Leukocyte transendothelial migration hsa04071 KEGG Pathway Sphingolipid signaling pathway hsa04360 KEGG Pathway Axon guidance hsa04960 KEGG Pathway Aldosterone-regulated sodium reabsorption hsa04929 KEGG Pathway GnRH secretion hsa05221 KEGG Pathway Acute myeloid leukemia hsa04150 KEGG Pathway mTOR signaling pathway hsa04152 KEGG Pathway AMPK signaling pathway hsa04550 KEGG Pathway Signaling pathways regulating pluripotency of stem cells hsa04666 KEGG Pathway Fc gamma R-mediated phagocytosis hsa04810 KEGG Pathway Regulation of actin cytoskeleton hsa04650 KEGG Pathway Natural killer cell mediated cytotoxicity hsa05017 KEGG Pathway Spinocerebellar ataxia hsa00562 KEGG Pathway Inositol phosphate metabolism hsa04144 KEGG Pathway Endocytosis hsa00785 KEGG Pathway Lipoic acid metabolism hsa00061 KEGG Pathway Fatty acid biosynthesis hsa01212 KEGG Pathway Fatty acid metabolism hsa04977 KEGG Pathway Vitamin digestion and absorption hsa00220 KEGG Pathway Arginine biosynthesis hsa00250 KEGG Pathway Alanine, aspartate and glutamate metabolism hsa01230 KEGG Pathway Biosynthesis of amino acids hsa00471 KEGG Pathway D-Glutamine and D-glutamate metabolism hsa04964 KEGG Pathway Proximal tubule bicarbonate reclamation hsa00910 KEGG Pathway Nitrogen metabolism hsa01210 KEGG Pathway 2-Oxocarboxylic acid metabolism hsa00330 KEGG Pathway Arginine and proline metabolism hsa00400 KEGG Pathway Phenylalanine, tyrosine and tryptophan biosynthesis hsa00360 KEGG Pathway Phenylalanine metabolism hsa00020 KEGG Pathway Citrate cycle (TCA cycle) hsa00270 KEGG Pathway Cysteine and methionine metabolism hsa00310 KEGG Pathway Lysine degradation hsa04146 KEGG Pathway Peroxisome hsa04974 KEGG Pathway Protein digestion and absorption hsa00340 KEGG Pathway Histidine metabolism hsa00053 KEGG Pathway Ascorbate and aldarate metabolism hsa00410 KEGG Pathway beta-Alanine metabolism hsa00620 KEGG Pathway Pyruvate metabolism hsa00071 KEGG Pathway Fatty acid degradation hsa00280 KEGG Pathway Valine, leucine and isoleucine degradation hsa00561 KEGG Pathway Glycerolipid metabolism hsa00770 KEGG Pathway Pantothenate and CoA biosynthesis hsa00260 KEGG Pathway Glycine, serine and threonine metabolism hsa00140 KEGG Pathway Steroid hormone biosynthesis hsa00982 KEGG Pathway Drug metabolism - cytochrome P450 hsa00040 KEGG Pathway Pentose and glucuronate interconversions hsa00600 KEGG Pathway Sphingolipid metabolism hsa00240 KEGG Pathway Pyrimidine metabolism hsa04710 KEGG Pathway Circadian rhythm hsa05410 KEGG Pathway Hypertrophic cardiomyopathy hsa04136 KEGG Pathway Autophagy - other hsa00980 KEGG Pathway Metabolism of xenobiotics by cytochrome P450 hsa03440 KEGG Pathway Homologous recombination hsa04622 KEGG Pathway RIG-I-like receptor signaling pathway hsa03030 KEGG Pathway DNA replication hsa03430 KEGG Pathway Mismatch repair hsa03420 KEGG Pathway Nucleotide excision repair hsa03410 KEGG Pathway Base excision repair hsa00565 KEGG Pathway Ether lipid metabolism hsa00230 KEGG Pathway Purine metabolism hsa00564 KEGG Pathway Glycerophospholipid metabolism hsa03008 KEGG Pathway Ribosome biogenesis in eukaryotes hsa00100 KEGG Pathway Steroid biosynthesis hsa00983 KEGG Pathway Drug metabolism - other enzymes hsa00860 KEGG Pathway Porphyrin and chlorophyll metabolism hsa00830 KEGG Pathway Retinol metabolism hsa02010 KEGG Pathway ABC transporters hsa04966 KEGG Pathway Collecting duct acid secretion hsa00480 KEGG Pathway Glutathione metabolism hsa00670 KEGG Pathway One carbon pool by folate hsa04614 KEGG Pathway Renin-angiotensin system hsa04610 KEGG Pathway Complement and coagulation cascades hsa03010 KEGG Pathway Ribosome hsa04145 KEGG Pathway Phagosome hsa00232 KEGG Pathway Caffeine metabolism hsa05412 KEGG Pathway Arrhythmogenic right ventricular cardiomyopathy hsa04260 KEGG Pathway Cardiac muscle contraction hsa03320 KEGG Pathway PPAR signaling pathway hsa00190 KEGG Pathway Oxidative phosphorylation hsa04979 KEGG Pathway Cholesterol metabolism hsa00640 KEGG Pathway Propanoate metabolism hsa00430 KEGG Pathway Taurine and hypotaurine metabolism hsa00450 KEGG Pathway Selenocompound metabolism hsa00630 KEGG Pathway Glyoxylate and dicarboxylate metabolism hsa03460 KEGG Pathway Fanconi anemia pathway hsa00650 KEGG Pathway Butanoate metabolism hsa04940 KEGG Pathway Type I diabetes mellitus hsa00030 KEGG Pathway Pentose phosphate pathway hsa05033 KEGG Pathway Nicotine addiction hsa00120 KEGG Pathway Primary bile acid biosynthesis hsa05330 KEGG Pathway Allograft rejection hsa05310 KEGG Pathway Asthma hsa04672 KEGG Pathway Intestinal immune network for IgA production hsa05320 KEGG Pathway Autoimmune thyroid disease hsa03040 KEGG Pathway Spliceosome hsa04975 KEGG Pathway Fat digestion and absorption hsa05150 KEGG Pathway Staphylococcus aureus infection hsa05217 KEGG Pathway Basal cell carcinoma hsa04978 KEGG Pathway Mineral absorption hsa03013 KEGG Pathway RNA transport