Data Description file for Dataset: Neighbour Enrichment - RCTM Description: Dataset of target annotations collected using the Neibhour Enrichment function in STRING, which includes annotations from nearest neighbour proteins to the input target. The predictive features in this dataset refer only to category of Pathways sourced from Reactome. Special Columns: Category Description Index ID Unique identifier for the compound/sex combination (instance) in the data. Ignored when training the classification model. Compound_name ID Name of the compound (drug). Ignored when training the classification model. class Target Variable Class label, with 0 indicating that the drug/sex combination is NOT associated with mouse longevity, and 1 indicating that it IS associated with mouse longevity, based on results from peer-reviewed studies. Predictive Features: Category Description HSA-373076 Reactome Pathway Class A/1 (Rhodopsin-like receptors) HSA-388396 Reactome Pathway GPCR downstream signalling HSA-418594 Reactome Pathway G alpha (i) signalling events HSA-375276 Reactome Pathway Peptide ligand-binding receptors HSA-416476 Reactome Pathway G alpha (q) signalling events HSA-8943724 Reactome Pathway Regulation of PTEN gene transcription HSA-6804758 Reactome Pathway Regulation of TP53 Activity through Acetylation HSA-3214815 Reactome Pathway HDACs deacetylate histones HSA-3247509 Reactome Pathway Chromatin modifying enzymes HSA-74160 Reactome Pathway Gene expression (Transcription) HSA-162582 Reactome Pathway Signal Transduction HSA-1643685 Reactome Pathway Disease HSA-212165 Reactome Pathway Epigenetic regulation of gene expression HSA-212436 Reactome Pathway Generic Transcription Pathway HSA-3108232 Reactome Pathway SUMO E3 ligases SUMOylate target proteins HSA-9679506 Reactome Pathway SARS-CoV Infections HSA-2122947 Reactome Pathway NOTCH1 Intracellular Domain Regulates Transcription HSA-2173793 Reactome Pathway Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HSA-157118 Reactome Pathway Signaling by NOTCH HSA-5663205 Reactome Pathway Infectious disease HSA-2644606 Reactome Pathway Constitutive Signaling by NOTCH1 PEST Domain Mutants HSA-2894862 Reactome Pathway Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSA-5250913 Reactome Pathway Positive epigenetic regulation of rRNA expression HSA-73854 Reactome Pathway RNA Polymerase I Promoter Clearance HSA-9006931 Reactome Pathway Signaling by Nuclear Receptors HSA-5617472 Reactome Pathway Activation of anterior HOX genes in hindbrain development during early embryogenesis HSA-6811555 Reactome Pathway PI5P Regulates TP53 Acetylation HSA-9701898 Reactome Pathway STAT3 nuclear events downstream of ALK signaling HSA-9679191 Reactome Pathway Potential therapeutics for SARS HSA-4641265 Reactome Pathway Repression of WNT target genes HSA-9005891 Reactome Pathway Loss of function of MECP2 in Rett syndrome HSA-2559584 Reactome Pathway Formation of Senescence-Associated Heterochromatin Foci (SAHF) HSA-9018519 Reactome Pathway Estrogen-dependent gene expression HSA-6804114 Reactome Pathway TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest HSA-6804760 Reactome Pathway Regulation of TP53 Activity through Methylation HSA-5663202 Reactome Pathway Diseases of signal transduction by growth factor receptors and second messengers HSA-983231 Reactome Pathway Factors involved in megakaryocyte development and platelet production HSA-350054 Reactome Pathway Notch-HLH transcription pathway HSA-2173795 Reactome Pathway Downregulation of SMAD2/3:SMAD4 transcriptional activity HSA-69278 Reactome Pathway Cell Cycle, Mitotic HSA-9022692 Reactome Pathway Regulation of MECP2 expression and activity HSA-201681 Reactome Pathway TCF dependent signaling in response to WNT HSA-2559585 Reactome Pathway Oncogene Induced Senescence HSA-8864260 Reactome Pathway Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors HSA-2173796 Reactome Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription HSA-9029569 Reactome Pathway NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HSA-3769402 Reactome Pathway Deactivation of the beta-catenin transactivating complex HSA-3899300 Reactome Pathway SUMOylation of transcription cofactors HSA-427389 Reactome Pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression HSA-73762 Reactome Pathway RNA Polymerase I Transcription Initiation HSA-9707616 Reactome Pathway Heme signaling HSA-9758941 Reactome Pathway Gastrulation HSA-5688426 Reactome Pathway Deubiquitination HSA-201722 Reactome Pathway Formation of the beta-catenin:TCF transactivating complex HSA-1912408 Reactome Pathway Pre-NOTCH Transcription and Translation HSA-2262752 Reactome Pathway Cellular responses to stress HSA-597592 Reactome Pathway Post-translational protein modification HSA-73894 Reactome Pathway DNA Repair HSA-9614085 Reactome Pathway FOXO-mediated transcription HSA-8936459 Reactome Pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function HSA-400253 Reactome Pathway Circadian Clock HSA-427413 Reactome Pathway NoRC negatively regulates rRNA expression HSA-381340 Reactome Pathway Transcriptional regulation of white adipocyte differentiation HSA-8878159 Reactome Pathway Transcriptional regulation by RUNX3 HSA-5696398 Reactome Pathway Nucleotide Excision Repair HSA-1989781 Reactome Pathway PPARA activates gene expression HSA-8986944 Reactome Pathway Transcriptional Regulation by MECP2 HSA-9022537 Reactome Pathway Loss of MECP2 binding ability to the NCoR/SMRT complex HSA-9609690 Reactome Pathway HCMV Early Events HSA-400206 Reactome Pathway Regulation of lipid metabolism by PPARalpha HSA-9707564 Reactome Pathway Cytoprotection by HMOX1 HSA-1266738 Reactome Pathway Developmental Biology HSA-2151201 Reactome Pathway Transcriptional activation of mitochondrial biogenesis HSA-1368071 Reactome Pathway NR1D1 (REV-ERBA) represses gene expression HSA-383280 Reactome Pathway Nuclear Receptor transcription pathway HSA-9623433 Reactome Pathway NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis HSA-1368082 Reactome Pathway RORA activates gene expression HSA-1368108 Reactome Pathway BMAL1:CLOCK,NPAS2 activates circadian gene expression HSA-8953750 Reactome Pathway Transcriptional Regulation by E2F6 HSA-212300 Reactome Pathway PRC2 methylates histones and DNA HSA-2426168 Reactome Pathway Activation of gene expression by SREBF (SREBP) HSA-9710421 Reactome Pathway Defective pyroptosis HSA-3214841 Reactome Pathway PKMTs methylate histone lysines HSA-2559580 Reactome Pathway Oxidative Stress Induced Senescence HSA-8941284 Reactome Pathway RUNX2 regulates chondrocyte maturation HSA-1852241 Reactome Pathway Organelle biogenesis and maintenance HSA-198753 Reactome Pathway ERK/MAPK targets HSA-525793 Reactome Pathway Myogenesis HSA-9006934 Reactome Pathway Signaling by Receptor Tyrosine Kinases HSA-9705683 Reactome Pathway SARS-CoV-2-host interactions HSA-1280215 Reactome Pathway Cytokine Signaling in Immune system HSA-4551638 Reactome Pathway SUMOylation of chromatin organization proteins HSA-380259 Reactome Pathway Loss of Nlp from mitotic centrosomes HSA-8854518 Reactome Pathway AURKA Activation by TPX2 HSA-380270 Reactome Pathway Recruitment of mitotic centrosome proteins and complexes HSA-2565942 Reactome Pathway Regulation of PLK1 Activity at G2/M Transition HSA-68886 Reactome Pathway M Phase HSA-3371556 Reactome Pathway Cellular response to heat stress HSA-380320 Reactome Pathway Recruitment of NuMA to mitotic centrosomes HSA-5620912 Reactome Pathway Anchoring of the basal body to the plasma membrane HSA-211000 Reactome Pathway Gene Silencing by RNA HSA-449147 Reactome Pathway Signaling by Interleukins HSA-500792 Reactome Pathway GPCR ligand binding HSA-381771 Reactome Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) HSA-418555 Reactome Pathway G alpha (s) signalling events HSA-5625886 Reactome Pathway Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 HSA-194315 Reactome Pathway Signaling by Rho GTPases HSA-195258 Reactome Pathway RHO GTPase Effectors HSA-3371497 Reactome Pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSA-5336415 Reactome Pathway Uptake and function of diphtheria toxin HSA-3371511 Reactome Pathway HSF1 activation HSA-3371568 Reactome Pathway Attenuation phase HSA-9796292 Reactome Pathway Formation of axial mesoderm HSA-399954 Reactome Pathway Sema3A PAK dependent Axon repulsion HSA-9613829 Reactome Pathway Chaperone Mediated Autophagy HSA-9013418 Reactome Pathway RHOBTB2 GTPase cycle HSA-5218920 Reactome Pathway VEGFR2 mediated vascular permeability HSA-2029482 Reactome Pathway Regulation of actin dynamics for phagocytic cup formation HSA-8939211 Reactome Pathway ESR-mediated signaling HSA-9009391 Reactome Pathway Extra-nuclear estrogen signaling HSA-1251985 Reactome Pathway Nuclear signaling by ERBB4 HSA-9024446 Reactome Pathway NR1H2 and NR1H3-mediated signaling HSA-450341 Reactome Pathway Activation of the AP-1 family of transcription factors HSA-193807 Reactome Pathway Synthesis of bile acids and bile salts via 27-hydroxycholesterol HSA-159418 Reactome Pathway Recycling of bile acids and salts HSA-193368 Reactome Pathway Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol HSA-2559583 Reactome Pathway Cellular Senescence HSA-211976 Reactome Pathway Endogenous sterols HSA-2871796 Reactome Pathway FCERI mediated MAPK activation HSA-1227986 Reactome Pathway Signaling by ERBB2 HSA-1257604 Reactome Pathway PIP3 activates AKT signaling HSA-1430728 Reactome Pathway Metabolism HSA-6796648 Reactome Pathway TP53 Regulates Transcription of DNA Repair Genes HSA-5683057 Reactome Pathway MAPK family signaling cascades HSA-2219530 Reactome Pathway Constitutive Signaling by Aberrant PI3K in Cancer HSA-9663891 Reactome Pathway Selective autophagy HSA-2559582 Reactome Pathway Senescence-Associated Secretory Phenotype (SASP) HSA-5687128 Reactome Pathway MAPK6/MAPK4 signaling HSA-2029480 Reactome Pathway Fcgamma receptor (FCGR) dependent phagocytosis HSA-4420097 Reactome Pathway VEGFA-VEGFR2 Pathway HSA-3214847 Reactome Pathway HATs acetylate histones HSA-6785807 Reactome Pathway Interleukin-4 and Interleukin-13 signaling HSA-6811558 Reactome Pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling HSA-187037 Reactome Pathway Signaling by NTRK1 (TRKA) HSA-168249 Reactome Pathway Innate Immune System HSA-8878166 Reactome Pathway Transcriptional regulation by RUNX2 HSA-556833 Reactome Pathway Metabolism of lipids HSA-9735871 Reactome Pathway SARS-CoV-1 targets host intracellular signalling and regulatory pathways HSA-8863795 Reactome Pathway Downregulation of ERBB2 signaling HSA-9665348 Reactome Pathway Signaling by ERBB2 ECD mutants HSA-9665686 Reactome Pathway Signaling by ERBB2 TMD/JMD mutants HSA-9664565 Reactome Pathway Signaling by ERBB2 KD Mutants HSA-9652282 Reactome Pathway Drug-mediated inhibition of ERBB2 signaling HSA-9665233 Reactome Pathway Resistance of ERBB2 KD mutants to trastuzumab HSA-9665244 Reactome Pathway Resistance of ERBB2 KD mutants to sapitinib HSA-9665245 Reactome Pathway Resistance of ERBB2 KD mutants to tesevatinib HSA-9665246 Reactome Pathway Resistance of ERBB2 KD mutants to neratinib HSA-9665247 Reactome Pathway Resistance of ERBB2 KD mutants to osimertinib HSA-9665249 Reactome Pathway Resistance of ERBB2 KD mutants to afatinib HSA-9665250 Reactome Pathway Resistance of ERBB2 KD mutants to AEE788 HSA-9665251 Reactome Pathway Resistance of ERBB2 KD mutants to lapatinib HSA-9665737 Reactome Pathway Drug resistance in ERBB2 TMD/JMD mutants HSA-5218859 Reactome Pathway Regulated Necrosis HSA-9634285 Reactome Pathway Constitutive Signaling by Overexpressed ERBB2 HSA-5637810 Reactome Pathway Constitutive Signaling by EGFRvIII HSA-1236382 Reactome Pathway Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants HSA-5675482 Reactome Pathway Regulation of necroptotic cell death HSA-8848021 Reactome Pathway Signaling by PTK6 HSA-1251932 Reactome Pathway PLCG1 events in ERBB2 signaling HSA-8866910 Reactome Pathway TFAP2 (AP-2) family regulates transcription of growth factors and their receptors HSA-8847993 Reactome Pathway ERBB2 Activates PTK6 Signaling HSA-6785631 Reactome Pathway ERBB2 Regulates Cell Motility HSA-1963640 Reactome Pathway GRB2 events in ERBB2 signaling HSA-1963642 Reactome Pathway PI3K events in ERBB2 signaling HSA-1250196 Reactome Pathway SHC1 events in ERBB2 signaling HSA-373755 Reactome Pathway Semaphorin interactions HSA-8939902 Reactome Pathway Regulation of RUNX2 expression and activity HSA-8852276 Reactome Pathway The role of GTSE1 in G2/M progression after G2 checkpoint HSA-168928 Reactome Pathway DDX58/IFIH1-mediated induction of interferon-alpha/beta HSA-8937144 Reactome Pathway Aryl hydrocarbon receptor signalling HSA-1234174 Reactome Pathway Cellular response to hypoxia HSA-1234158 Reactome Pathway Regulation of gene expression by Hypoxia-inducible Factor HSA-1234176 Reactome Pathway Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HSA-9768919 Reactome Pathway NPAS4 regulates expression of target genes HSA-3134973 Reactome Pathway LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HSA-9818028 Reactome Pathway NFE2L2 regulates pentose phosphate pathway genes HSA-9617629 Reactome Pathway Regulation of FOXO transcriptional activity by acetylation HSA-168256 Reactome Pathway Immune System HSA-8866907 Reactome Pathway Activation of the TFAP2 (AP-2) family of transcription factors HSA-3700989 Reactome Pathway Transcriptional Regulation by TP53 HSA-8941856 Reactome Pathway RUNX3 regulates NOTCH signaling HSA-918233 Reactome Pathway TRAF3-dependent IRF activation pathway HSA-9614657 Reactome Pathway FOXO-mediated transcription of cell death genes HSA-210744 Reactome Pathway Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells HSA-9818027 Reactome Pathway NFE2L2 regulating anti-oxidant/detoxification enzymes HSA-6803204 Reactome Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release HSA-9013695 Reactome Pathway NOTCH4 Intracellular Domain Regulates Transcription HSA-5621575 Reactome Pathway CD209 (DC-SIGN) signaling HSA-9793380 Reactome Pathway Formation of paraxial mesoderm HSA-211981 Reactome Pathway Xenobiotics HSA-9013508 Reactome Pathway NOTCH3 Intracellular Domain Regulates Transcription HSA-933541 Reactome Pathway TRAF6 mediated IRF7 activation HSA-69275 Reactome Pathway G2/M Transition HSA-8951664 Reactome Pathway Neddylation HSA-9694516 Reactome Pathway SARS-CoV-2 Infection HSA-9705671 Reactome Pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses HSA-1474244 Reactome Pathway Extracellular matrix organization HSA-3000170 Reactome Pathway Syndecan interactions HSA-1566948 Reactome Pathway Elastic fibre formation HSA-1566977 Reactome Pathway Fibronectin matrix formation HSA-216083 Reactome Pathway Integrin cell surface interactions HSA-202733 Reactome Pathway Cell surface interactions at the vascular wall HSA-3000157 Reactome Pathway Laminin interactions HSA-8874081 Reactome Pathway MET activates PTK2 signaling HSA-2129379 Reactome Pathway Molecules associated with elastic fibres HSA-111459 Reactome Pathway Activation of caspases through apoptosome-mediated cleavage HSA-111463 Reactome Pathway SMAC (DIABLO) binds to IAPs HSA-111464 Reactome Pathway SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes HSA-5357801 Reactome Pathway Programmed Cell Death HSA-109606 Reactome Pathway Intrinsic Pathway for Apoptosis HSA-109581 Reactome Pathway Apoptosis HSA-9627069 Reactome Pathway Regulation of the apoptosome activity HSA-5357786 Reactome Pathway TNFR1-induced proapoptotic signaling HSA-168638 Reactome Pathway NOD1/2 Signaling Pathway HSA-5357905 Reactome Pathway Regulation of TNFR1 signaling HSA-73887 Reactome Pathway Death Receptor Signaling HSA-5357769 Reactome Pathway Caspase activation via extrinsic apoptotic signalling pathway HSA-5357956 Reactome Pathway TNFR1-induced NFkappaB signaling pathway HSA-111465 Reactome Pathway Apoptotic cleavage of cellular proteins HSA-418889 Reactome Pathway Caspase activation via Dependence Receptors in the absence of ligand HSA-168164 Reactome Pathway Toll Like Receptor 3 (TLR3) Cascade HSA-264870 Reactome Pathway Caspase-mediated cleavage of cytoskeletal proteins HSA-937061 Reactome Pathway TRIF(TICAM1)-mediated TLR4 signaling HSA-198323 Reactome Pathway AKT phosphorylates targets in the cytosol HSA-168927 Reactome Pathway TICAM1, RIP1-mediated IKK complex recruitment HSA-5676594 Reactome Pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway HSA-937041 Reactome Pathway IKK complex recruitment mediated by RIP1 HSA-5674400 Reactome Pathway Constitutive Signaling by AKT1 E17K in Cancer HSA-5620971 Reactome Pathway Pyroptosis HSA-422356 Reactome Pathway Regulation of insulin secretion HSA-111885 Reactome Pathway Opioid Signalling HSA-392170 Reactome Pathway ADP signalling through P2Y purinoceptor 12 HSA-202040 Reactome Pathway G-protein activation HSA-400042 Reactome Pathway Adrenaline,noradrenaline inhibits insulin secretion HSA-420092 Reactome Pathway Glucagon-type ligand receptors HSA-381676 Reactome Pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion HSA-9634597 Reactome Pathway GPER1 signaling HSA-9660821 Reactome Pathway ADORA2B mediated anti-inflammatory cytokines production HSA-991365 Reactome Pathway Activation of GABAB receptors HSA-418597 Reactome Pathway G alpha (z) signalling events HSA-8964315 Reactome Pathway G beta:gamma signalling through BTK HSA-392851 Reactome Pathway Prostacyclin signalling through prostacyclin receptor HSA-418217 Reactome Pathway G beta:gamma signalling through PLC beta HSA-8964616 Reactome Pathway G beta:gamma signalling through CDC42 HSA-500657 Reactome Pathway Presynaptic function of Kainate receptors HSA-428930 Reactome Pathway Thromboxane signalling through TP receptor HSA-392451 Reactome Pathway G beta:gamma signalling through PI3Kgamma HSA-418592 Reactome Pathway ADP signalling through P2Y purinoceptor 1 HSA-1296041 Reactome Pathway Activation of G protein gated Potassium channels HSA-9615017 Reactome Pathway FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes HSA-997272 Reactome Pathway Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits HSA-456926 Reactome Pathway Thrombin signalling through proteinase activated receptors (PARs) HSA-163359 Reactome Pathway Glucagon signaling in metabolic regulation HSA-6814122 Reactome Pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding HSA-432040 Reactome Pathway Vasopressin regulates renal water homeostasis via Aquaporins HSA-4086398 Reactome Pathway Ca2+ pathway HSA-416482 Reactome Pathway G alpha (12/13) signalling events HSA-2980736 Reactome Pathway Peptide hormone metabolism HSA-5250924 Reactome Pathway B-WICH complex positively regulates rRNA expression HSA-73728 Reactome Pathway RNA Polymerase I Promoter Opening HSA-5334118 Reactome Pathway DNA methylation HSA-110330 Reactome Pathway Recognition and association of DNA glycosylase with site containing an affected purine HSA-110331 Reactome Pathway Cleavage of the damaged purine HSA-427359 Reactome Pathway SIRT1 negatively regulates rRNA expression HSA-68616 Reactome Pathway Assembly of the ORC complex at the origin of replication HSA-2299718 Reactome Pathway Condensation of Prophase Chromosomes HSA-9670095 Reactome Pathway Inhibition of DNA recombination at telomere HSA-912446 Reactome Pathway Meiotic recombination HSA-73772 Reactome Pathway RNA Polymerase I Promoter Escape HSA-9616222 Reactome Pathway Transcriptional regulation of granulopoiesis HSA-2559586 Reactome Pathway DNA Damage/Telomere Stress Induced Senescence HSA-5578749 Reactome Pathway Transcriptional regulation by small RNAs HSA-977225 Reactome Pathway Amyloid fiber formation HSA-8939236 Reactome Pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs HSA-3214858 Reactome Pathway RMTs methylate histone arginines HSA-392499 Reactome Pathway Metabolism of proteins HSA-9610379 Reactome Pathway HCMV Late Events HSA-5689901 Reactome Pathway Metalloprotease DUBs HSA-5693571 Reactome Pathway Nonhomologous End-Joining (NHEJ) HSA-5689880 Reactome Pathway Ub-specific processing proteases HSA-5693565 Reactome Pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HSA-69473 Reactome Pathway G2/M DNA damage checkpoint HSA-5693607 Reactome Pathway Processing of DNA double-strand break ends HSA-5689603 Reactome Pathway UCH proteinases HSA-9711123 Reactome Pathway Cellular response to chemical stress HSA-9619665 Reactome Pathway EGR2 and SOX10-mediated initiation of Schwann cell myelination HSA-198725 Reactome Pathway Nuclear Events (kinase and transcription factor activation) HSA-9006925 Reactome Pathway Intracellular signaling by second messengers HSA-9612973 Reactome Pathway Autophagy HSA-9646399 Reactome Pathway Aggrephagy HSA-9755511 Reactome Pathway KEAP1-NFE2L2 pathway HSA-9759194 Reactome Pathway Nuclear events mediated by NFE2L2 HSA-9664873 Reactome Pathway Pexophagy HSA-5689877 Reactome Pathway Josephin domain DUBs HSA-209543 Reactome Pathway p75NTR recruits signalling complexes HSA-209560 Reactome Pathway NF-kB is activated and signals survival HSA-205043 Reactome Pathway NRIF signals cell death from the nucleus HSA-110320 Reactome Pathway Translesion Synthesis by POLH HSA-5205685 Reactome Pathway PINK1-PRKN Mediated Mitophagy HSA-8940973 Reactome Pathway RUNX2 regulates osteoblast differentiation HSA-8878171 Reactome Pathway Transcriptional regulation by RUNX1 HSA-9615710 Reactome Pathway Late endosomal microautophagy HSA-5689896 Reactome Pathway Ovarian tumor domain proteases HSA-6781823 Reactome Pathway Formation of TC-NER Pre-Incision Complex HSA-8866654 Reactome Pathway E3 ubiquitin ligases ubiquitinate target proteins HSA-8941858 Reactome Pathway Regulation of RUNX3 expression and activity HSA-168643 Reactome Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways HSA-5362768 Reactome Pathway Hh mutants are degraded by ERAD HSA-5678895 Reactome Pathway Defective CFTR causes cystic fibrosis HSA-1834949 Reactome Pathway Cytosolic sensors of pathogen-associated DNA HSA-5358346 Reactome Pathway Hedgehog ligand biogenesis HSA-6782135 Reactome Pathway Dual incision in TC-NER HSA-6782210 Reactome Pathway Gap-filling DNA repair synthesis and ligation in TC-NER HSA-9013694 Reactome Pathway Signaling by NOTCH4 HSA-9692914 Reactome Pathway SARS-CoV-1-host interactions HSA-382556 Reactome Pathway ABC-family proteins mediated transport HSA-9012999 Reactome Pathway RHO GTPase cycle HSA-9020702 Reactome Pathway Interleukin-1 signaling HSA-6798695 Reactome Pathway Neutrophil degranulation HSA-5621481 Reactome Pathway C-type lectin receptors (CLRs) HSA-5633007 Reactome Pathway Regulation of TP53 Activity HSA-193670 Reactome Pathway p75NTR negatively regulates cell cycle via SC1 HSA-9022699 Reactome Pathway MECP2 regulates neuronal receptors and channels HSA-68882 Reactome Pathway Mitotic Anaphase HSA-2500257 Reactome Pathway Resolution of Sister Chromatid Cohesion HSA-69242 Reactome Pathway S Phase HSA-2467813 Reactome Pathway Separation of Sister Chromatids HSA-3108214 Reactome Pathway SUMOylation of DNA damage response and repair proteins HSA-8939243 Reactome Pathway RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known HSA-196807 Reactome Pathway Nicotinate metabolism HSA-196849 Reactome Pathway Metabolism of water-soluble vitamins and cofactors HSA-8982491 Reactome Pathway Glycogen metabolism HSA-70221 Reactome Pathway Glycogen breakdown (glycogenolysis) HSA-189085 Reactome Pathway Digestion of dietary carbohydrate HSA-5663084 Reactome Pathway Diseases of carbohydrate metabolism HSA-3229121 Reactome Pathway Glycogen storage diseases HSA-70171 Reactome Pathway Glycolysis HSA-71387 Reactome Pathway Metabolism of carbohydrates HSA-2142753 Reactome Pathway Arachidonic acid metabolism HSA-2162123 Reactome Pathway Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSA-9025094 Reactome Pathway Biosynthesis of DPAn-3 SPMs HSA-6783783 Reactome Pathway Interleukin-10 signaling HSA-9018679 Reactome Pathway Biosynthesis of EPA-derived SPMs HSA-9018677 Reactome Pathway Biosynthesis of DHA-derived SPMs HSA-9026286 Reactome Pathway Biosynthesis of DPAn-3-derived protectins and resolvins HSA-9027604 Reactome Pathway Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives HSA-9023661 Reactome Pathway Biosynthesis of E-series 18(R)-resolvins HSA-2142770 Reactome Pathway Synthesis of 15-eicosatetraenoic acid derivatives HSA-9018896 Reactome Pathway Biosynthesis of E-series 18(S)-resolvins HSA-197264 Reactome Pathway Nicotinamide salvaging HSA-2142691 Reactome Pathway Synthesis of Leukotrienes (LT) and Eoxins (EX) HSA-446652 Reactome Pathway Interleukin-1 family signaling HSA-8853884 Reactome Pathway Transcriptional Regulation by VENTX HSA-9025106 Reactome Pathway Biosynthesis of DPAn-6 SPMs HSA-9026290 Reactome Pathway Biosynthesis of DPAn-3-derived maresins HSA-211859 Reactome Pathway Biological oxidations HSA-2142700 Reactome Pathway Synthesis of Lipoxins (LX) HSA-2142712 Reactome Pathway Synthesis of 12-eicosatetraenoic acid derivatives HSA-211945 Reactome Pathway Phase I - Functionalization of compounds HSA-442720 Reactome Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase HSA-180024 Reactome Pathway DARPP-32 events HSA-9664323 Reactome Pathway FCGR3A-mediated IL10 synthesis HSA-382551 Reactome Pathway Transport of small molecules HSA-9634600 Reactome Pathway Regulation of glycolysis by fructose 2,6-bisphosphate metabolism HSA-2672351 Reactome Pathway Stimuli-sensing channels HSA-3295583 Reactome Pathway TRP channels HSA-8853659 Reactome Pathway RET signaling HSA-5610780 Reactome Pathway Degradation of GLI1 by the proteasome HSA-5610783 Reactome Pathway Degradation of GLI2 by the proteasome HSA-5610785 Reactome Pathway GLI3 is processed to GLI3R by the proteasome HSA-109582 Reactome Pathway Hemostasis HSA-5578775 Reactome Pathway Ion homeostasis HSA-1280218 Reactome Pathway Adaptive Immune System HSA-375280 Reactome Pathway Amine ligand-binding receptors HSA-112311 Reactome Pathway Neurotransmitter clearance HSA-390666 Reactome Pathway Serotonin receptors HSA-379398 Reactome Pathway Enzymatic degradation of Dopamine by monoamine oxidase HSA-379397 Reactome Pathway Enzymatic degradation of dopamine by COMT HSA-380615 Reactome Pathway Serotonin clearance from the synaptic cleft HSA-209931 Reactome Pathway Serotonin and melatonin biosynthesis HSA-112315 Reactome Pathway Transmission across Chemical Synapses HSA-181430 Reactome Pathway Norepinephrine Neurotransmitter Release Cycle HSA-372790 Reactome Pathway Signaling by GPCR HSA-76002 Reactome Pathway Platelet activation, signaling and aggregation HSA-170670 Reactome Pathway Adenylate cyclase inhibitory pathway HSA-2219528 Reactome Pathway PI3K/AKT Signaling in Cancer HSA-1660499 Reactome Pathway Synthesis of PIPs at the plasma membrane HSA-912631 Reactome Pathway Regulation of signaling by CBL HSA-9006335 Reactome Pathway Signaling by Erythropoietin HSA-912526 Reactome Pathway Interleukin receptor SHC signaling HSA-114604 Reactome Pathway GPVI-mediated activation cascade HSA-198203 Reactome Pathway PI3K/AKT activation HSA-9027276 Reactome Pathway Erythropoietin activates Phosphoinositide-3-kinase (PI3K) HSA-9673767 Reactome Pathway Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants HSA-9673770 Reactome Pathway Signaling by PDGFRA extracellular domain mutants HSA-112399 Reactome Pathway IRS-mediated signalling HSA-210993 Reactome Pathway Tie2 Signaling HSA-9670439 Reactome Pathway Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants HSA-389357 Reactome Pathway CD28 dependent PI3K/Akt signaling HSA-201556 Reactome Pathway Signaling by ALK HSA-186763 Reactome Pathway Downstream signal transduction HSA-2424491 Reactome Pathway DAP12 signaling HSA-1433557 Reactome Pathway Signaling by SCF-KIT HSA-109704 Reactome Pathway PI3K Cascade HSA-5673001 Reactome Pathway RAF/MAP kinase cascade HSA-422475 Reactome Pathway Axon guidance HSA-9034015 Reactome Pathway Signaling by NTRK3 (TRKC) HSA-2730905 Reactome Pathway Role of LAT2/NTAL/LAB on calcium mobilization HSA-373753 Reactome Pathway Nephrin family interactions HSA-1266695 Reactome Pathway Interleukin-7 signaling HSA-2029485 Reactome Pathway Role of phospholipids in phagocytosis HSA-9680350 Reactome Pathway Signaling by CSF1 (M-CSF) in myeloid cells HSA-9607240 Reactome Pathway FLT3 Signaling HSA-2454202 Reactome Pathway Fc epsilon receptor (FCERI) signaling HSA-9603381 Reactome Pathway Activated NTRK3 signals through PI3K HSA-177929 Reactome Pathway Signaling by EGFR HSA-1236394 Reactome Pathway Signaling by ERBB4 HSA-5655291 Reactome Pathway Signaling by FGFR4 in disease HSA-9703648 Reactome Pathway Signaling by FLT3 ITD and TKD mutants HSA-9013404 Reactome Pathway RAC2 GTPase cycle HSA-180292 Reactome Pathway GAB1 signalosome HSA-202424 Reactome Pathway Downstream TCR signaling HSA-9703465 Reactome Pathway Signaling by FLT3 fusion proteins HSA-5655332 Reactome Pathway Signaling by FGFR3 in disease HSA-5654708 Reactome Pathway Downstream signaling of activated FGFR3 HSA-9006115 Reactome Pathway Signaling by NTRK2 (TRKB) HSA-5654716 Reactome Pathway Downstream signaling of activated FGFR4 HSA-5654696 Reactome Pathway Downstream signaling of activated FGFR2 HSA-5654687 Reactome Pathway Downstream signaling of activated FGFR1 HSA-5655302 Reactome Pathway Signaling by FGFR1 in disease HSA-5655253 Reactome Pathway Signaling by FGFR2 in disease HSA-9013149 Reactome Pathway RAC1 GTPase cycle HSA-9725370 Reactome Pathway Signaling by ALK fusions and activated point mutants HSA-8851907 Reactome Pathway MET activates PI3K/AKT signaling HSA-112412 Reactome Pathway SOS-mediated signalling HSA-9028335 Reactome Pathway Activated NTRK2 signals through PI3K HSA-6806834 Reactome Pathway Signaling by MET HSA-2179392 Reactome Pathway EGFR Transactivation by Gastrin HSA-1250342 Reactome Pathway PI3K events in ERBB4 signaling HSA-179812 Reactome Pathway GRB2 events in EGFR signaling HSA-983705 Reactome Pathway Signaling by the B Cell Receptor (BCR) HSA-180336 Reactome Pathway SHC1 events in EGFR signaling HSA-1839117 Reactome Pathway Signaling by cytosolic FGFR1 fusion mutants HSA-5654710 Reactome Pathway PI-3K cascade:FGFR3 HSA-5654720 Reactome Pathway PI-3K cascade:FGFR4 HSA-5654689 Reactome Pathway PI-3K cascade:FGFR1 HSA-5654695 Reactome Pathway PI-3K cascade:FGFR2 HSA-9634638 Reactome Pathway Estrogen-dependent nuclear events downstream of ESR-membrane signaling HSA-983695 Reactome Pathway Antigen activates B Cell Receptor (BCR) leading to generation of second messengers HSA-9013420 Reactome Pathway RHOU GTPase cycle HSA-9035034 Reactome Pathway RHOF GTPase cycle HSA-9696264 Reactome Pathway RND3 GTPase cycle HSA-9696273 Reactome Pathway RND1 GTPase cycle HSA-9696270 Reactome Pathway RND2 GTPase cycle HSA-9013405 Reactome Pathway RHOD GTPase cycle HSA-9013409 Reactome Pathway RHOJ GTPase cycle HSA-9013026 Reactome Pathway RHOB GTPase cycle HSA-9013423 Reactome Pathway RAC3 GTPase cycle HSA-8980692 Reactome Pathway RHOA GTPase cycle HSA-9013148 Reactome Pathway CDC42 GTPase cycle HSA-389356 Reactome Pathway CD28 co-stimulation HSA-397795 Reactome Pathway G-protein beta:gamma signalling HSA-182971 Reactome Pathway EGFR downregulation HSA-9013424 Reactome Pathway RHOV GTPase cycle HSA-9013408 Reactome Pathway RHOG GTPase cycle HSA-8849473 Reactome Pathway PTK6 Expression HSA-452723 Reactome Pathway Transcriptional regulation of pluripotent stem cells HSA-389661 Reactome Pathway Glyoxylate metabolism and glycine degradation HSA-196780 Reactome Pathway Biotin transport and metabolism HSA-425407 Reactome Pathway SLC-mediated transmembrane transport HSA-425366 Reactome Pathway Transport of bile salts and organic acids, metal ions and amine compounds HSA-5619102 Reactome Pathway SLC transporter disorders HSA-199220 Reactome Pathway Vitamin B5 (pantothenate) metabolism HSA-1362409 Reactome Pathway Mitochondrial iron-sulfur cluster biogenesis HSA-8964539 Reactome Pathway Glutamate and glutamine metabolism HSA-71291 Reactome Pathway Metabolism of amino acids and derivatives HSA-70263 Reactome Pathway Gluconeogenesis HSA-8963693 Reactome Pathway Aspartate and asparagine metabolism HSA-210500 Reactome Pathway Glutamate Neurotransmitter Release Cycle HSA-1614635 Reactome Pathway Sulfur amino acid metabolism HSA-9033241 Reactome Pathway Peroxisomal protein import HSA-1442490 Reactome Pathway Collagen degradation HSA-419037 Reactome Pathway NCAM1 interactions HSA-3000178 Reactome Pathway ECM proteoglycans HSA-3000480 Reactome Pathway Scavenging by Class A Receptors HSA-71384 Reactome Pathway Ethanol oxidation HSA-209905 Reactome Pathway Catecholamine biosynthesis HSA-141333 Reactome Pathway Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB HSA-430116 Reactome Pathway GP1b-IX-V activation signalling HSA-76009 Reactome Pathway Platelet Aggregation (Plug Formation) HSA-877300 Reactome Pathway Interferon gamma signaling HSA-70326 Reactome Pathway Glucose metabolism HSA-8956320 Reactome Pathway Nucleotide biosynthesis HSA-15869 Reactome Pathway Metabolism of nucleotides HSA-500753 Reactome Pathway Pyrimidine biosynthesis HSA-434316 Reactome Pathway Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion HSA-390696 Reactome Pathway Adrenoceptors HSA-399997 Reactome Pathway Acetylcholine regulates insulin secretion HSA-2514859 Reactome Pathway Inactivation, recovery and regulation of the phototransduction cascade HSA-9717207 Reactome Pathway Sensory perception of sweet, bitter, and umami (glutamate) taste HSA-112043 Reactome Pathway PLC beta mediated events HSA-380972 Reactome Pathway Energy dependent regulation of mTOR by LKB1-AMPK HSA-5628897 Reactome Pathway TP53 Regulates Metabolic Genes HSA-1632852 Reactome Pathway Macroautophagy HSA-9619483 Reactome Pathway Activation of AMPK downstream of NMDARs HSA-9613354 Reactome Pathway Lipophagy HSA-2151209 Reactome Pathway Activation of PPARGC1A (PGC-1alpha) by phosphorylation HSA-6804756 Reactome Pathway Regulation of TP53 Activity through Phosphorylation HSA-1445148 Reactome Pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane HSA-163680 Reactome Pathway AMPK inhibits chREBP transcriptional activation activity HSA-200425 Reactome Pathway Carnitine metabolism HSA-163685 Reactome Pathway Integration of energy metabolism HSA-199991 Reactome Pathway Membrane Trafficking HSA-3371571 Reactome Pathway HSF1-dependent transactivation HSA-166208 Reactome Pathway mTORC1-mediated signalling HSA-9639288 Reactome Pathway Amino acids regulate mTORC1 HSA-3322077 Reactome Pathway Glycogen synthesis HSA-112409 Reactome Pathway RAF-independent MAPK1/3 activation HSA-5675221 Reactome Pathway Negative regulation of MAPK pathway HSA-166058 Reactome Pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane HSA-9652169 Reactome Pathway Signaling by MAP2K mutants HSA-975138 Reactome Pathway TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation HSA-975871 Reactome Pathway MyD88 cascade initiated on plasma membrane HSA-5674499 Reactome Pathway Negative feedback regulation of MAPK pathway HSA-450294 Reactome Pathway MAP kinase activation HSA-170968 Reactome Pathway Frs2-mediated activation HSA-445144 Reactome Pathway Signal transduction by L1 HSA-373760 Reactome Pathway L1CAM interactions HSA-450282 Reactome Pathway MAPK targets/ Nuclear events mediated by MAP kinases HSA-6802948 Reactome Pathway Signaling by high-kinase activity BRAF mutants HSA-5674135 Reactome Pathway MAP2K and MAPK activation HSA-9656223 Reactome Pathway Signaling by RAF1 mutants HSA-6802946 Reactome Pathway Signaling by moderate kinase activity BRAF mutants HSA-6802955 Reactome Pathway Paradoxical activation of RAF signaling by kinase inactive BRAF HSA-9649948 Reactome Pathway Signaling downstream of RAS mutants HSA-6802952 Reactome Pathway Signaling by BRAF and RAF1 fusions HSA-444257 Reactome Pathway RSK activation HSA-112411 Reactome Pathway MAPK1 (ERK2) activation HSA-5210891 Reactome Pathway Uptake and function of anthrax toxins HSA-1295596 Reactome Pathway Spry regulation of FGF signaling HSA-881907 Reactome Pathway Gastrin-CREB signalling pathway via PKC and MAPK HSA-9725371 Reactome Pathway Nuclear events stimulated by ALK signaling in cancer HSA-9008059 Reactome Pathway Interleukin-37 signaling HSA-982772 Reactome Pathway Growth hormone receptor signaling HSA-9734009 Reactome Pathway Defective Intrinsic Pathway for Apoptosis HSA-5673000 Reactome Pathway RAF activation HSA-390471 Reactome Pathway Association of TriC/CCT with target proteins during biosynthesis HSA-437239 Reactome Pathway Recycling pathway of L1 HSA-9635465 Reactome Pathway Suppression of apoptosis HSA-110056 Reactome Pathway MAPK3 (ERK1) activation HSA-74749 Reactome Pathway Signal attenuation HSA-202670 Reactome Pathway ERKs are inactivated HSA-879415 Reactome Pathway Advanced glycosylation endproduct receptor signaling HSA-162658 Reactome Pathway Golgi Cisternae Pericentriolar Stack Reorganization HSA-1502540 Reactome Pathway Signaling by Activin HSA-5635838 Reactome Pathway Activation of SMO HSA-1181150 Reactome Pathway Signaling by NODAL HSA-5668599 Reactome Pathway RHO GTPases Activate NADPH Oxidases HSA-2122948 Reactome Pathway Activated NOTCH1 Transmits Signal to the Nucleus HSA-5663213 Reactome Pathway RHO GTPases Activate WASPs and WAVEs HSA-375165 Reactome Pathway NCAM signaling for neurite out-growth HSA-9664422 Reactome Pathway FCGR3A-mediated phagocytosis HSA-3371453 Reactome Pathway Regulation of HSF1-mediated heat shock response HSA-8856825 Reactome Pathway Cargo recognition for clathrin-mediated endocytosis HSA-389359 Reactome Pathway CD28 dependent Vav1 pathway HSA-5627123 Reactome Pathway RHO GTPases activate PAKs HSA-428540 Reactome Pathway Activation of RAC1 HSA-2682334 Reactome Pathway EPH-Ephrin signaling HSA-3928664 Reactome Pathway Ephrin signaling HSA-202433 Reactome Pathway Generation of second messenger molecules HSA-376176 Reactome Pathway Signaling by ROBO receptors HSA-9013406 Reactome Pathway RHOQ GTPase cycle HSA-8950505 Reactome Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation HSA-9013407 Reactome Pathway RHOH GTPase cycle HSA-3928662 Reactome Pathway EPHB-mediated forward signaling HSA-445355 Reactome Pathway Smooth Muscle Contraction HSA-373752 Reactome Pathway Netrin-1 signaling HSA-450531 Reactome Pathway Regulation of mRNA stability by proteins that bind AU-rich elements HSA-198765 Reactome Pathway Signalling to ERK5 HSA-8957322 Reactome Pathway Metabolism of steroids HSA-193048 Reactome Pathway Androgen biosynthesis HSA-193775 Reactome Pathway Synthesis of bile acids and bile salts via 24-hydroxycholesterol HSA-194002 Reactome Pathway Glucocorticoid biosynthesis HSA-193993 Reactome Pathway Mineralocorticoid biosynthesis HSA-1640170 Reactome Pathway Cell Cycle HSA-6804757 Reactome Pathway Regulation of TP53 Degradation HSA-69620 Reactome Pathway Cell Cycle Checkpoints HSA-114452 Reactome Pathway Activation of BH3-only proteins HSA-69541 Reactome Pathway Stabilization of p53 HSA-6803207 Reactome Pathway TP53 Regulates Transcription of Caspase Activators and Caspases HSA-6804759 Reactome Pathway Regulation of TP53 Activity through Association with Co-factors HSA-3232118 Reactome Pathway SUMOylation of transcription factors HSA-5693532 Reactome Pathway DNA Double-Strand Break Repair HSA-9709570 Reactome Pathway Impaired BRCA2 binding to RAD51 HSA-5685938 Reactome Pathway HDR through Single Strand Annealing (SSA) HSA-5693616 Reactome Pathway Presynaptic phase of homologous DNA pairing and strand exchange HSA-349425 Reactome Pathway Autodegradation of the E3 ubiquitin ligase COP1 HSA-157579 Reactome Pathway Telomere Maintenance HSA-381183 Reactome Pathway ATF6 (ATF6-alpha) activates chaperone genes HSA-983170 Reactome Pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC HSA-901042 Reactome Pathway Calnexin/calreticulin cycle HSA-442742 Reactome Pathway CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling HSA-187687 Reactome Pathway Signalling to ERKs HSA-5654741 Reactome Pathway Signaling by FGFR3 HSA-5654743 Reactome Pathway Signaling by FGFR4 HSA-5654736 Reactome Pathway Signaling by FGFR1 HSA-5654738 Reactome Pathway Signaling by FGFR2 HSA-9034864 Reactome Pathway Activated NTRK3 signals through RAS HSA-2428933 Reactome Pathway SHC-related events triggered by IGF1R HSA-9026519 Reactome Pathway Activated NTRK2 signals through RAS HSA-8851805 Reactome Pathway MET activates RAS signaling HSA-9028731 Reactome Pathway Activated NTRK2 signals through FRS2 and FRS3 HSA-171007 Reactome Pathway p38MAPK events HSA-1250347 Reactome Pathway SHC1 events in ERBB4 signaling HSA-8849471 Reactome Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases HSA-9027284 Reactome Pathway Erythropoietin activates RAS HSA-5218921 Reactome Pathway VEGFR2 mediated cell proliferation HSA-5654704 Reactome Pathway SHC-mediated cascade:FGFR3 HSA-442982 Reactome Pathway Ras activation upon Ca2+ influx through NMDA receptor HSA-5654706 Reactome Pathway FRS-mediated FGFR3 signaling HSA-5654719 Reactome Pathway SHC-mediated cascade:FGFR4 HSA-5654688 Reactome Pathway SHC-mediated cascade:FGFR1 HSA-5654712 Reactome Pathway FRS-mediated FGFR4 signaling HSA-5654693 Reactome Pathway FRS-mediated FGFR1 signaling HSA-5654699 Reactome Pathway SHC-mediated cascade:FGFR2 HSA-9648002 Reactome Pathway RAS processing HSA-5654700 Reactome Pathway FRS-mediated FGFR2 signaling HSA-5658442 Reactome Pathway Regulation of RAS by GAPs HSA-1169091 Reactome Pathway Activation of NF-kappaB in B cells HSA-2871837 Reactome Pathway FCERI mediated NF-kB activation HSA-5607764 Reactome Pathway CLEC7A (Dectin-1) signaling HSA-5684264 Reactome Pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation HSA-1810476 Reactome Pathway RIP-mediated NFkB activation via ZBP1 HSA-933542 Reactome Pathway TRAF6 mediated NF-kB activation HSA-5603029 Reactome Pathway IkBA variant leads to EDA-ID HSA-445989 Reactome Pathway TAK1-dependent IKK and NF-kappa-B activation HSA-5607761 Reactome Pathway Dectin-1 mediated noncanonical NF-kB signaling HSA-5602636 Reactome Pathway IKBKB deficiency causes SCID HSA-5603027 Reactome Pathway IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) HSA-983169 Reactome Pathway Class I MHC mediated antigen processing & presentation HSA-5676590 Reactome Pathway NIK-->noncanonical NF-kB signaling HSA-4755510 Reactome Pathway SUMOylation of immune response proteins HSA-933543 Reactome Pathway NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 HSA-937039 Reactome Pathway IRAK1 recruits IKK complex HSA-975144 Reactome Pathway IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation HSA-1170546 Reactome Pathway Prolactin receptor signaling HSA-9758274 Reactome Pathway Regulation of NF-kappa B signaling HSA-9692916 Reactome Pathway SARS-CoV-1 activates/modulates innate immune responses HSA-9762114 Reactome Pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 HSA-174113 Reactome Pathway SCF-beta-TrCP mediated degradation of Emi1 HSA-2644607 Reactome Pathway Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling HSA-5660668 Reactome Pathway CLEC7A/inflammasome pathway HSA-3134963 Reactome Pathway DEx/H-box helicases activate type I IFN and inflammatory cytokines production HSA-195253 Reactome Pathway Degradation of beta-catenin by the destruction complex HSA-1236974 Reactome Pathway ER-Phagosome pathway HSA-448706 Reactome Pathway Interleukin-1 processing HSA-193692 Reactome Pathway Regulated proteolysis of p75NTR HSA-9708530 Reactome Pathway Regulation of BACH1 activity HSA-844456 Reactome Pathway The NLRP3 inflammasome HSA-9660826 Reactome Pathway Purinergic signaling in leishmaniasis infection HSA-69231 Reactome Pathway Cyclin D associated events in G1 HSA-180534 Reactome Pathway Vpu mediated degradation of CD4 HSA-9604323 Reactome Pathway Negative regulation of NOTCH4 signaling HSA-8854050 Reactome Pathway FBXL7 down-regulates AURKA during mitotic entry and in early mitosis HSA-187577 Reactome Pathway SCF(Skp2)-mediated degradation of p27/p21 HSA-917937 Reactome Pathway Iron uptake and transport HSA-983168 Reactome Pathway Antigen processing: Ubiquitination & Proteasome degradation HSA-68949 Reactome Pathway Orc1 removal from chromatin HSA-1474228 Reactome Pathway Degradation of the extracellular matrix HSA-622312 Reactome Pathway Inflammasomes HSA-844615 Reactome Pathway The AIM2 inflammasome HSA-844623 Reactome Pathway The IPAF inflammasome HSA-5626978 Reactome Pathway TNFR1-mediated ceramide production HSA-5668541 Reactome Pathway TNFR2 non-canonical NF-kB pathway HSA-450321 Reactome Pathway JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 HSA-450302 Reactome Pathway Activated TAK1 mediates p38 MAPK activation HSA-9661069 Reactome Pathway Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) HSA-453279 Reactome Pathway Mitotic G1 phase and G1/S transition HSA-69206 Reactome Pathway G1/S Transition HSA-69202 Reactome Pathway Cyclin E associated events during G1/S transition HSA-69656 Reactome Pathway Cyclin A:Cdk2-associated events at S phase entry HSA-8849470 Reactome Pathway PTK6 Regulates Cell Cycle HSA-9630794 Reactome Pathway Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 HSA-9632700 Reactome Pathway Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 HSA-9754119 Reactome Pathway Drug-mediated inhibition of CDK4/CDK6 activity HSA-6791312 Reactome Pathway TP53 Regulates Transcription of Cell Cycle Genes HSA-6804116 Reactome Pathway TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest HSA-69563 Reactome Pathway p53-Dependent G1 DNA Damage Response HSA-174143 Reactome Pathway APC/C-mediated degradation of cell cycle proteins HSA-8934593 Reactome Pathway Regulation of RUNX1 Expression and Activity HSA-9617828 Reactome Pathway FOXO-mediated transcription of cell cycle genes HSA-69273 Reactome Pathway Cyclin A/B1/B2 associated events during G2/M transition HSA-1538133 Reactome Pathway G0 and Early G1 HSA-75815 Reactome Pathway Ubiquitin-dependent degradation of Cyclin D HSA-176408 Reactome Pathway Regulation of APC/C activators between G1/S and early anaphase HSA-5651801 Reactome Pathway PCNA-Dependent Long Patch Base Excision Repair HSA-5696397 Reactome Pathway Gap-filling DNA repair synthesis and ligation in GG-NER HSA-5656169 Reactome Pathway Termination of translesion DNA synthesis HSA-5685942 Reactome Pathway HDR through Homologous Recombination (HRR) HSA-110314 Reactome Pathway Recognition of DNA damage by PCNA-containing replication complex HSA-5696400 Reactome Pathway Dual Incision in GG-NER HSA-110312 Reactome Pathway Translesion synthesis by REV1 HSA-5655862 Reactome Pathway Translesion synthesis by POLK HSA-5656121 Reactome Pathway Translesion synthesis by POLI HSA-176187 Reactome Pathway Activation of ATR in response to replication stress HSA-5358565 Reactome Pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) HSA-5358606 Reactome Pathway Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HSA-69166 Reactome Pathway Removal of the Flap Intermediate HSA-174437 Reactome Pathway Removal of the Flap Intermediate from the C-strand HSA-110362 Reactome Pathway POLB-Dependent Long Patch Base Excision Repair HSA-1660662 Reactome Pathway Glycosphingolipid metabolism HSA-5668914 Reactome Pathway Diseases of metabolism HSA-139853 Reactome Pathway Elevation of cytosolic Ca2+ levels HSA-74259 Reactome Pathway Purine catabolism HSA-1483191 Reactome Pathway Synthesis of PC HSA-1483206 Reactome Pathway Glycerophospholipid biosynthesis HSA-1483213 Reactome Pathway Synthesis of PE HSA-975110 Reactome Pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling HSA-9693928 Reactome Pathway Defective RIPK1-mediated regulated necrosis HSA-3371378 Reactome Pathway Regulation by c-FLIP HSA-5218900 Reactome Pathway CASP8 activity is inhibited HSA-69416 Reactome Pathway Dimerization of procaspase-8 HSA-141444 Reactome Pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal HSA-9648025 Reactome Pathway EML4 and NUDC in mitotic spindle formation HSA-5663220 Reactome Pathway RHO GTPases Activate Formins HSA-174048 Reactome Pathway APC/C:Cdc20 mediated degradation of Cyclin B HSA-69478 Reactome Pathway G2/M DNA replication checkpoint HSA-176417 Reactome Pathway Phosphorylation of Emi1 HSA-2980767 Reactome Pathway Activation of NIMA Kinases NEK9, NEK6, NEK7 HSA-2514853 Reactome Pathway Condensation of Prometaphase Chromosomes HSA-174184 Reactome Pathway Cdc20:Phospho-APC/C mediated degradation of Cyclin A HSA-174178 Reactome Pathway APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 HSA-2995383 Reactome Pathway Initiation of Nuclear Envelope (NE) Reformation HSA-176412 Reactome Pathway Phosphorylation of the APC/C HSA-179409 Reactome Pathway APC-Cdc20 mediated degradation of Nek2A HSA-3301854 Reactome Pathway Nuclear Pore Complex (NPC) Disassembly HSA-113507 Reactome Pathway E2F-enabled inhibition of pre-replication complex formation HSA-2465910 Reactome Pathway MASTL Facilitates Mitotic Progression HSA-75035 Reactome Pathway Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex HSA-4419969 Reactome Pathway Depolymerisation of the Nuclear Lamina HSA-174154 Reactome Pathway APC/C:Cdc20 mediated degradation of Securin HSA-5696394 Reactome Pathway DNA Damage Recognition in GG-NER HSA-171319 Reactome Pathway Telomere Extension By Telomerase HSA-191273 Reactome Pathway Cholesterol biosynthesis HSA-5607763 Reactome Pathway CLEC7A (Dectin-1) induces NFAT activation HSA-114508 Reactome Pathway Effects of PIP2 hydrolysis HSA-2871809 Reactome Pathway FCERI mediated Ca+2 mobilization HSA-5576891 Reactome Pathway Cardiac conduction HSA-5576890 Reactome Pathway Phase 3 - rapid repolarisation HSA-5576893 Reactome Pathway Phase 2 - plateau phase HSA-1296071 Reactome Pathway Potassium Channels HSA-1296072 Reactome Pathway Voltage gated Potassium channels HSA-5576892 Reactome Pathway Phase 0 - rapid depolarisation HSA-156580 Reactome Pathway Phase II - Conjugation of compounds HSA-156588 Reactome Pathway Glucuronidation HSA-9748784 Reactome Pathway Drug ADME HSA-9749641 Reactome Pathway Aspirin ADME HSA-9753281 Reactome Pathway Paracetamol ADME HSA-5579029 Reactome Pathway Metabolic disorders of biological oxidation enzymes HSA-189483 Reactome Pathway Heme degradation HSA-3000171 Reactome Pathway Non-integrin membrane-ECM interactions HSA-9027307 Reactome Pathway Biosynthesis of maresin-like SPMs HSA-9754706 Reactome Pathway Atorvastatin ADME HSA-211999 Reactome Pathway CYP2E1 reactions HSA-2161517 Reactome Pathway Abacavir transmembrane transport HSA-2142670 Reactome Pathway Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) HSA-2142816 Reactome Pathway Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) HSA-9757110 Reactome Pathway Prednisone ADME HSA-442729 Reactome Pathway CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde HSA-111932 Reactome Pathway CaMK IV-mediated phosphorylation of CREB HSA-9619229 Reactome Pathway Activation of RAC1 downstream of NMDARs HSA-9617324 Reactome Pathway Negative regulation of NMDA receptor-mediated neuronal transmission HSA-71288 Reactome Pathway Creatine metabolism HSA-390522 Reactome Pathway Striated Muscle Contraction HSA-397014 Reactome Pathway Muscle contraction HSA-1247673 Reactome Pathway Erythrocytes take up oxygen and release carbon dioxide HSA-1237044 Reactome Pathway Erythrocytes take up carbon dioxide and release oxygen HSA-425381 Reactome Pathway Bicarbonate transporters HSA-1475029 Reactome Pathway Reversible hydration of carbon dioxide HSA-425393 Reactome Pathway Transport of inorganic cations/anions and amino acids/oligopeptides HSA-77387 Reactome Pathway Insulin receptor recycling HSA-917977 Reactome Pathway Transferrin endocytosis and recycling HSA-983712 Reactome Pathway Ion channel transport HSA-1222556 Reactome Pathway ROS and RNS production in phagocytes HSA-9018678 Reactome Pathway Biosynthesis of specialized proresolving mediators (SPMs) HSA-2142688 Reactome Pathway Synthesis of 5-eicosatetraenoic acids HSA-9020265 Reactome Pathway Biosynthesis of aspirin-triggered D-series resolvins HSA-9018676 Reactome Pathway Biosynthesis of D-series resolvins HSA-9018682 Reactome Pathway Biosynthesis of maresins HSA-3299685 Reactome Pathway Detoxification of Reactive Oxygen Species HSA-5652227 Reactome Pathway Fructose biosynthesis HSA-5661270 Reactome Pathway Formation of xylulose-5-phosphate HSA-1474151 Reactome Pathway Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation HSA-196757 Reactome Pathway Metabolism of folate and pterines HSA-196854 Reactome Pathway Metabolism of vitamins and cofactors HSA-422085 Reactome Pathway Synthesis, secretion, and deacylation of Ghrelin HSA-189200 Reactome Pathway Cellular hexose transport HSA-8981373 Reactome Pathway Intestinal hexose absorption HSA-420499 Reactome Pathway Class C/3 (Metabotropic glutamate/pheromone receptors) HSA-2022377 Reactome Pathway Metabolism of Angiotensinogen to Angiotensins HSA-6807070 Reactome Pathway PTEN Regulation HSA-8866652 Reactome Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes HSA-186712 Reactome Pathway Regulation of beta-cell development HSA-156902 Reactome Pathway Peptide chain elongation HSA-192823 Reactome Pathway Viral mRNA Translation HSA-2408557 Reactome Pathway Selenocysteine synthesis HSA-72764 Reactome Pathway Eukaryotic Translation Termination HSA-975956 Reactome Pathway Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) HSA-72689 Reactome Pathway Formation of a pool of free 40S subunits HSA-9633012 Reactome Pathway Response of EIF2AK4 (GCN2) to amino acid deficiency HSA-156827 Reactome Pathway L13a-mediated translational silencing of Ceruloplasmin expression HSA-1799339 Reactome Pathway SRP-dependent cotranslational protein targeting to membrane HSA-72706 Reactome Pathway GTP hydrolysis and joining of the 60S ribosomal subunit HSA-975957 Reactome Pathway Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) HSA-1592389 Reactome Pathway Activation of Matrix Metalloproteinases HSA-114608 Reactome Pathway Platelet degranulation HSA-381426 Reactome Pathway Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) HSA-391906 Reactome Pathway Leukotriene receptors HSA-211958 Reactome Pathway Miscellaneous substrates HSA-211979 Reactome Pathway Eicosanoids HSA-211935 Reactome Pathway Fatty acids HSA-140837 Reactome Pathway Intrinsic Pathway of Fibrin Clot Formation HSA-140875 Reactome Pathway Common Pathway of Fibrin Clot Formation HSA-8957275 Reactome Pathway Post-translational protein phosphorylation HSA-354194 Reactome Pathway GRB2:SOS provides linkage to MAPK signaling for Integrins HSA-372708 Reactome Pathway p130Cas linkage to MAPK signaling for integrins HSA-5602498 Reactome Pathway MyD88 deficiency (TLR2/4) HSA-5603041 Reactome Pathway IRAK4 deficiency (TLR2/4) HSA-5686938 Reactome Pathway Regulation of TLR by endogenous ligand HSA-9662001 Reactome Pathway Defective factor VIII causes hemophilia A HSA-159763 Reactome Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus HSA-159740 Reactome Pathway Gamma-carboxylation of protein precursors HSA-159782 Reactome Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins HSA-1500931 Reactome Pathway Cell-Cell communication HSA-5626467 Reactome Pathway RHO GTPases activate IQGAPs HSA-156590 Reactome Pathway Glutathione conjugation HSA-9018681 Reactome Pathway Biosynthesis of protectins HSA-5423646 Reactome Pathway Aflatoxin activation and detoxification HSA-9748787 Reactome Pathway Azathioprine ADME HSA-75893 Reactome Pathway TNF signaling HSA-9686347 Reactome Pathway Microbial modulation of RIPK1-mediated regulated necrosis HSA-9013957 Reactome Pathway TLR3-mediated TICAM1-dependent programmed cell death HSA-2562578 Reactome Pathway TRIF-mediated programmed cell death HSA-937042 Reactome Pathway IRAK2 mediated activation of TAK1 complex HSA-9014325 Reactome Pathway TICAM1,TRAF6-dependent induction of TAK1 complex HSA-9645460 Reactome Pathway Alpha-protein kinase 1 signaling pathway HSA-975163 Reactome Pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation HSA-937072 Reactome Pathway TRAF6-mediated induction of TAK1 complex within TLR4 complex HSA-5669034 Reactome Pathway TNFs bind their physiological receptors HSA-936964 Reactome Pathway Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HSA-211897 Reactome Pathway Cytochrome P450 - arranged by substrate type HSA-442660 Reactome Pathway Na+/Cl- dependent neurotransmitter transporters HSA-9694614 Reactome Pathway Attachment and Entry HSA-380994 Reactome Pathway ATF4 activates genes in response to endoplasmic reticulum stress HSA-181429 Reactome Pathway Serotonin Neurotransmitter Release Cycle HSA-212676 Reactome Pathway Dopamine Neurotransmitter Release Cycle HSA-112316 Reactome Pathway Neuronal System HSA-379401 Reactome Pathway Dopamine clearance from the synaptic cleft HSA-390651 Reactome Pathway Dopamine receptors HSA-112040 Reactome Pathway G-protein mediated events HSA-3858494 Reactome Pathway Beta-catenin independent WNT signaling HSA-2025928 Reactome Pathway Calcineurin activates NFAT HSA-203615 Reactome Pathway eNOS activation HSA-392154 Reactome Pathway Nitric oxide stimulates guanylate cyclase HSA-400508 Reactome Pathway Incretin synthesis, secretion, and inactivation HSA-390650 Reactome Pathway Histamine receptors HSA-112314 Reactome Pathway Neurotransmitter receptors and postsynaptic signal transmission HSA-947581 Reactome Pathway Molybdenum cofactor biosynthesis HSA-5576886 Reactome Pathway Phase 4 - resting membrane potential HSA-6799198 Reactome Pathway Complex I biogenesis HSA-1428517 Reactome Pathway The citric acid (TCA) cycle and respiratory electron transport HSA-71403 Reactome Pathway Citric acid cycle (TCA cycle) HSA-611105 Reactome Pathway Respiratory electron transport HSA-70268 Reactome Pathway Pyruvate metabolism HSA-1660517 Reactome Pathway Synthesis of PIPs at the late endosome membrane HSA-1660514 Reactome Pathway Synthesis of PIPs at the Golgi membrane HSA-1660516 Reactome Pathway Synthesis of PIPs at the early endosome membrane HSA-4090294 Reactome Pathway SUMOylation of intracellular receptors HSA-9017802 Reactome Pathway Noncanonical activation of NOTCH3 HSA-9013700 Reactome Pathway NOTCH4 Activation and Transmission of Signal to the Nucleus HSA-2979096 Reactome Pathway NOTCH2 Activation and Transmission of Signal to the Nucleus HSA-174403 Reactome Pathway Glutathione synthesis and recycling HSA-5578999 Reactome Pathway Defective GCLC causes HAGGSD HSA-9664535 Reactome Pathway LTC4-CYSLTR mediated IL4 production HSA-71406 Reactome Pathway Pyruvate metabolism and Citric Acid (TCA) cycle HSA-8963691 Reactome Pathway Phenylalanine and tyrosine metabolism HSA-71240 Reactome Pathway Tryptophan catabolism HSA-1614558 Reactome Pathway Degradation of cysteine and homocysteine HSA-2408508 Reactome Pathway Metabolism of ingested SeMet, Sec, MeSec into H2Se HSA-156581 Reactome Pathway Methylation HSA-3359467 Reactome Pathway Defective MTRR causes HMAE HSA-3359469 Reactome Pathway Defective MTR causes HMAG HSA-9759218 Reactome Pathway Cobalamin (Cbl) metabolism HSA-379724 Reactome Pathway tRNA Aminoacylation HSA-379716 Reactome Pathway Cytosolic tRNA aminoacylation HSA-379726 Reactome Pathway Mitochondrial tRNA aminoacylation HSA-2408522 Reactome Pathway Selenoamino acid metabolism HSA-888568 Reactome Pathway GABA synthesis HSA-9022927 Reactome Pathway MECP2 regulates transcription of genes involved in GABA signaling HSA-977443 Reactome Pathway GABA receptor activation HSA-888593 Reactome Pathway Reuptake of GABA HSA-445095 Reactome Pathway Interaction between L1 and Ankyrins HSA-442755 Reactome Pathway Activation of NMDA receptors and postsynaptic events HSA-9609736 Reactome Pathway Assembly and cell surface presentation of NMDA receptors HSA-438066 Reactome Pathway Unblocking of NMDA receptors, glutamate binding and activation HSA-9620244 Reactome Pathway Long-term potentiation HSA-8849932 Reactome Pathway Synaptic adhesion-like molecules HSA-6794361 Reactome Pathway Neurexins and neuroligins HSA-451308 Reactome Pathway Activation of Ca-permeable Kainate Receptor HSA-447038 Reactome Pathway NrCAM interactions HSA-9032500 Reactome Pathway Activated NTRK2 signals through FYN HSA-399719 Reactome Pathway Trafficking of AMPA receptors HSA-5682910 Reactome Pathway LGI-ADAM interactions HSA-8979227 Reactome Pathway Triglyceride metabolism HSA-196071 Reactome Pathway Metabolism of steroid hormones HSA-193144 Reactome Pathway Estrogen biosynthesis HSA-8978868 Reactome Pathway Fatty acid metabolism HSA-75105 Reactome Pathway Fatty acyl-CoA biosynthesis HSA-75876 Reactome Pathway Synthesis of very long-chain fatty acyl-CoAs HSA-877312 Reactome Pathway Regulation of IFNG signaling HSA-8877330 Reactome Pathway RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) HSA-9020558 Reactome Pathway Interleukin-2 signaling HSA-8854691 Reactome Pathway Interleukin-20 family signaling HSA-9705462 Reactome Pathway Inactivation of CSF3 (G-CSF) signaling HSA-4641258 Reactome Pathway Degradation of DVL HSA-72163 Reactome Pathway mRNA Splicing - Major Pathway HSA-72165 Reactome Pathway mRNA Splicing - Minor Pathway HSA-163765 Reactome Pathway ChREBP activates metabolic gene expression HSA-9029558 Reactome Pathway NR1H2 & NR1H3 regulate gene expression linked to lipogenesis HSA-8849175 Reactome Pathway Threonine catabolism HSA-189451 Reactome Pathway Heme biosynthesis HSA-69481 Reactome Pathway G2/M Checkpoints HSA-6798163 Reactome Pathway Choline catabolism HSA-73817 Reactome Pathway Purine ribonucleoside monophosphate biosynthesis HSA-70635 Reactome Pathway Urea cycle HSA-352230 Reactome Pathway Amino acid transport across the plasma membrane HSA-210991 Reactome Pathway Basigin interactions HSA-428643 Reactome Pathway Organic anion transporters HSA-204174 Reactome Pathway Regulation of pyruvate dehydrogenase (PDH) complex HSA-1855204 Reactome Pathway Synthesis of IP3 and IP4 in the cytosol HSA-5358351 Reactome Pathway Signaling by Hedgehog HSA-381753 Reactome Pathway Olfactory Signaling Pathway HSA-170660 Reactome Pathway Adenylate cyclase activating pathway HSA-111933 Reactome Pathway Calmodulin induced events HSA-975634 Reactome Pathway Retinoid metabolism and transport HSA-75109 Reactome Pathway Triglyceride biosynthesis HSA-74217 Reactome Pathway Purine salvage HSA-418457 Reactome Pathway cGMP effects HSA-74713 Reactome Pathway IRS activation HSA-2428928 Reactome Pathway IRS-related events triggered by IGF1R HSA-2586552 Reactome Pathway Signaling by Leptin HSA-167044 Reactome Pathway Signalling to RAS HSA-354192 Reactome Pathway Integrin signaling HSA-9658195 Reactome Pathway Leishmania infection HSA-380612 Reactome Pathway Metabolism of serotonin HSA-389513 Reactome Pathway CTLA4 inhibitory signaling HSA-4641262 Reactome Pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane HSA-70895 Reactome Pathway Branched-chain amino acid catabolism HSA-9010553 Reactome Pathway Regulation of expression of SLITs and ROBOs HSA-6791226 Reactome Pathway Major pathway of rRNA processing in the nucleolus and cytosol HSA-1660661 Reactome Pathway Sphingolipid de novo biosynthesis HSA-392518 Reactome Pathway Signal amplification HSA-70921 Reactome Pathway Histidine catabolism HSA-6803157 Reactome Pathway Antimicrobial peptides HSA-1483166 Reactome Pathway Synthesis of PA HSA-5362517 Reactome Pathway Signaling by Retinoic Acid HSA-2132295 Reactome Pathway MHC class II antigen presentation HSA-6783310 Reactome Pathway Fanconi Anemia Pathway HSA-5696395 Reactome Pathway Formation of Incision Complex in GG-NER HSA-5685939 Reactome Pathway HDR through MMEJ (alt-NHEJ) HSA-111453 Reactome Pathway BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members HSA-9673324 Reactome Pathway WNT5:FZD7-mediated leishmania damping HSA-8948747 Reactome Pathway Regulation of PTEN localization HSA-9683683 Reactome Pathway Maturation of protein E HSA-9694493 Reactome Pathway Maturation of protein E HSA-9637628 Reactome Pathway Modulation by Mtb of host immune system HSA-9706377 Reactome Pathway FLT3 signaling by CBL mutants HSA-1253288 Reactome Pathway Downregulation of ERBB4 signaling HSA-3785653 Reactome Pathway Myoclonic epilepsy of Lafora HSA-8849469 Reactome Pathway PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 HSA-8876493 Reactome Pathway InlA-mediated entry of Listeria monocytogenes into host cells HSA-9636383 Reactome Pathway Prevention of phagosomal-lysosomal fusion HSA-9013973 Reactome Pathway TICAM1-dependent activation of IRF3/IRF7 HSA-1358803 Reactome Pathway Downregulation of ERBB2:ERBB3 signaling HSA-174490 Reactome Pathway Membrane binding and targetting of GAG proteins HSA-2691232 Reactome Pathway Constitutive Signaling by NOTCH1 HD Domain Mutants HSA-3134975 Reactome Pathway Regulation of innate immune responses to cytosolic DNA HSA-8875360 Reactome Pathway InlB-mediated entry of Listeria monocytogenes into host cell HSA-9706369 Reactome Pathway Negative regulation of FLT3 HSA-2173791 Reactome Pathway TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) HSA-8866427 Reactome Pathway VLDLR internalisation and degradation HSA-4641263 Reactome Pathway Regulation of FZD by ubiquitination HSA-6807004 Reactome Pathway Negative regulation of MET activity HSA-901032 Reactome Pathway ER Quality Control Compartment (ERQC) HSA-9013507 Reactome Pathway NOTCH3 Activation and Transmission of Signal to the Nucleus HSA-2173788 Reactome Pathway Downregulation of TGF-beta receptor signaling HSA-162588 Reactome Pathway Budding and maturation of HIV virion HSA-917729 Reactome Pathway Endosomal Sorting Complex Required For Transport (ESCRT) HSA-936440 Reactome Pathway Negative regulators of DDX58/IFIH1 signaling HSA-211733 Reactome Pathway Regulation of activated PAK-2p34 by proteasome mediated degradation HSA-69601 Reactome Pathway Ubiquitin Mediated Degradation of Phosphorylated Cdc25A HSA-180585 Reactome Pathway Vif-mediated degradation of APOBEC3G HSA-450408 Reactome Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA HSA-4641257 Reactome Pathway Degradation of AXIN HSA-174084 Reactome Pathway Autodegradation of Cdh1 by Cdh1:APC/C HSA-4608870 Reactome Pathway Asymmetric localization of PCP proteins HSA-8948751 Reactome Pathway Regulation of PTEN stability and activity HSA-69017 Reactome Pathway CDK-mediated phosphorylation and removal of Cdc6 HSA-1169408 Reactome Pathway ISG15 antiviral mechanism HSA-5632684 Reactome Pathway Hedgehog on state HSA-68867 Reactome Pathway Assembly of the pre-replicative complex HSA-198693 Reactome Pathway AKT phosphorylates targets in the nucleus HSA-9614399 Reactome Pathway Regulation of localization of FOXO transcription factors HSA-211163 Reactome Pathway AKT-mediated inactivation of FOXO1A HSA-9755779 Reactome Pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways HSA-199418 Reactome Pathway Negative regulation of the PI3K/AKT network HSA-165159 Reactome Pathway MTOR signalling HSA-350562 Reactome Pathway Regulation of ornithine decarboxylase (ODC) HSA-1296053 Reactome Pathway Classical Kir channels HSA-9027283 Reactome Pathway Erythropoietin activates STAT5 HSA-9675108 Reactome Pathway Nervous system development HSA-201688 Reactome Pathway WNT mediated activation of DVL HSA-8934903 Reactome Pathway Receptor Mediated Mitophagy HSA-390466 Reactome Pathway Chaperonin-mediated protein folding HSA-9022538 Reactome Pathway Loss of MECP2 binding ability to 5mC-DNA HSA-1483257 Reactome Pathway Phospholipid metabolism HSA-9022702 Reactome Pathway MECP2 regulates transcription of neuronal ligands HSA-72649 Reactome Pathway Translation initiation complex formation HSA-72702 Reactome Pathway Ribosomal scanning and start codon recognition HSA-1482925 Reactome Pathway Acyl chain remodelling of PG HSA-1482788 Reactome Pathway Acyl chain remodelling of PC HSA-1482801 Reactome Pathway Acyl chain remodelling of PS HSA-1482839 Reactome Pathway Acyl chain remodelling of PE HSA-418890 Reactome Pathway Role of second messengers in netrin-1 signaling HSA-2173789 Reactome Pathway TGF-beta receptor signaling activates SMADs HSA-195399 Reactome Pathway VEGF binds to VEGFR leading to receptor dimerization HSA-8953854 Reactome Pathway Metabolism of RNA HSA-203927 Reactome Pathway MicroRNA (miRNA) biogenesis HSA-198933 Reactome Pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell